The biggest enemy of Sherlock Holmes was Professor James Moriarty, often referred to as the "Napoleon of Crime". He is portrayed as a criminal mastermind who orchestrates various criminal activities from behind the scenes. Moriarty is a formidable opponent for Sherlock Holmes, matching him in intellect and cunning.
Moriarty appears in several stories, most notably in "The Adventure of the Final Problem," where he seemingly meets his demise in a dramatic confrontation with Holmes at the Reichenbach Falls. However, Moriarty's legacy continues to influence later stories and adaptations.
