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What enzymes break down neurotransmitters?

Published in Neurotransmitter Degradation 1 min read

Specific enzymes break down neurotransmitters in the synaptic cleft. These enzymes are crucial for regulating neurotransmitter levels and ensuring efficient neuronal signaling. Some examples of these enzymes and their corresponding neurotransmitters include:

  • Acetylcholinesterase: Breaks down acetylcholine, a neurotransmitter involved in muscle contraction and memory.
  • Monoamine oxidase (MAO): A family of enzymes that break down dopamine, norepinephrine, and serotonin, neurotransmitters involved in mood, motivation, and sleep.
  • Catechol-O-methyltransferase (COMT): Primarily degrades dopamine but also plays a role in the breakdown of norepinephrine.

These enzymes are essential for the proper function of the nervous system. Their activity can be influenced by various factors, including genetics, medications, and lifestyle choices.

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