RAS mutations are linked to a range of cancers, primarily affecting the following:
Common Cancers Associated with RAS Mutations:
- Lung Cancer: RAS mutations are common in non-small cell lung cancer (NSCLC), particularly adenocarcinoma.
- Colorectal Cancer: These mutations occur frequently in colorectal cancer, often contributing to tumor growth and spread.
- Pancreatic Cancer: RAS mutations are a significant factor in pancreatic ductal adenocarcinoma, a particularly aggressive form of the disease.
- Bladder Cancer: RAS mutations play a role in bladder cancer development and progression.
- Melanoma: While less common, RAS mutations can also occur in melanoma, a type of skin cancer.
How RAS Mutations Cause Cancer
RAS proteins are involved in cell signaling pathways that regulate cell growth and division. When these proteins are mutated, they become permanently "turned on," leading to uncontrolled cell growth and the development of cancer.
Treatment and Research
There are no specific treatments specifically targeting RAS mutations. However, ongoing research aims to develop therapies that effectively inhibit the activity of mutated RAS proteins, offering hope for future treatment options.
