AFAP stands for Atypical Familial Aggregation of Polyposis. It is a rare, inherited disorder that increases the risk of developing colorectal cancer.
Understanding AFAP
AFAP is characterized by the presence of numerous polyps (small growths) in the colon and rectum. These polyps are typically adenomatous, meaning they are noncancerous but have the potential to become cancerous over time.
Key Features of AFAP:
- Multiple polyps: Unlike other polyposis syndromes, AFAP does not have a specific number of polyps required for diagnosis.
- Variable penetrance: Not everyone who inherits the AFAP gene will develop polyps.
- Late onset: Symptoms usually appear later in life, often in the 40s or 50s.
Diagnosis and Management:
- Diagnosis: AFAP is diagnosed through a combination of family history, physical examination, and colonoscopy.
- Management: Regular colonoscopies are crucial for early detection and removal of polyps, reducing the risk of colorectal cancer.
