The most common KRAS mutation is G12D, which occurs in approximately 40% of KRAS-mutated cancers.
What is KRAS?
KRAS is a gene that encodes a protein involved in cell signaling pathways. When KRAS is mutated, it can lead to uncontrolled cell growth and cancer development.
Other Common KRAS Mutations
While G12D is the most frequent, several other mutations are also commonly found in KRAS-mutated cancers. These include:
- G12V
- G12R
- G12C
- G13D
Importance of KRAS Mutations
Identifying the specific KRAS mutation is crucial for several reasons:
- Targeted Therapy: Some targeted therapies are specific to certain KRAS mutations. For example, sotorasib (AMG510) is a KRAS G12C inhibitor.
- Prognosis: Different KRAS mutations may be associated with different cancer outcomes.
- Clinical Trials: Knowing the KRAS mutation status can help determine eligibility for clinical trials testing new therapies.
