Derek and Penelope are fictional characters from the popular TV show Grey's Anatomy. While the actors who play them, Patrick Dempsey and Sandra Oh, have a great rapport on and off-screen, there is no evidence to suggest they are close friends in real life. They have both moved on to other projects and have busy personal lives.
However, the actors have spoken fondly of their time working together on Grey's Anatomy and have maintained a professional relationship.
- Dempsey has mentioned that he enjoys working with Oh, and admires her talent.
- Oh has said that she has a lot of respect for Dempsey and values their time working together.
While they may not be close friends outside of work, it's clear that Dempsey and Oh have a strong bond and mutual respect for each other.
