Yes, there have been several female characters who have held the mantle of the Ghost Rider.
Notable Female Ghost Riders:
- Robbie Reyes' Sister, Alejandra: In the comics, Robbie Reyes' sister Alejandra became the Ghost Rider after inheriting the Spirit of Vengeance. She was introduced in the Ghost Rider series in 2014.
- Patsy Walker (Hellcat): Patsy Walker, known as Hellcat, briefly became a Ghost Rider in the Ghost Rider series in 2014. She was granted the powers of the Spirit of Vengeance by Mephisto.
- Danielle Cage (Ghost Rider): Danielle Cage, daughter of Luke Cage and Jessica Jones, briefly wielded the power of the Ghost Rider in the Ghost Rider series in 2014.
While these are the most notable, there have been other female characters who have briefly held the powers of the Ghost Rider in various storylines.
Note: This information is based on comic book storylines. There is currently no official female Ghost Rider in live-action adaptations.