The enzyme that controls histamine is histamine N-methyltransferase (HNMT).
HNMT is responsible for breaking down histamine in the body, effectively reducing its levels. This process is known as methylation.
HNMT is found in various tissues, including the brain, liver, and lungs. Its activity can be influenced by several factors, including genetics, age, and medications.
Here are some additional points about HNMT and its role in regulating histamine:
- HNMT deficiency: Individuals with a deficiency in HNMT may experience increased histamine levels, leading to symptoms like allergic reactions, headaches, and gastrointestinal issues.
- Medications: Some medications, like cimetidine, can inhibit HNMT activity, leading to a buildup of histamine.
- Other enzymes: While HNMT is the primary enzyme responsible for histamine breakdown, other enzymes, like diamine oxidase (DAO), also contribute to its metabolism.
