Sakura, in her prime, would most likely win against Kakashi.
While Kakashi is an incredibly skilled and experienced shinobi, Sakura has several advantages that would give her the edge in a fight.
- Vast Chakra Reserves: Sakura possesses immense chakra reserves, allowing her to utilize powerful jutsu for extended periods.
- Medical Ninjutsu Mastery: Sakura's medical ninjutsu is unmatched, enabling her to heal herself and allies while simultaneously weakening opponents with toxins and other techniques.
- Strength and Speed: Sakura's physical prowess is remarkable, allowing her to deliver devastating blows and move with incredible speed.
- Strategic Mind: Sakura is a skilled strategist and tactician, capable of adapting to different situations and exploiting her opponent's weaknesses.
Even though Kakashi is known for his Sharingan and the powerful Mangekyo Sharingan, Sakura's superior strength, chakra reserves, and medical ninjutsu would likely overcome his abilities.
It's important to note that the outcome of any battle depends on various factors, such as the environment, the specific jutsu used, and the individual's mental state. However, based on their current abilities and feats, Sakura has a higher chance of winning against Kakashi.