Sasuke Uchiha lost his parents when he was seven years old.
Sasuke's parents, Fugaku and Mikoto Uchiha, were murdered by his own brother, Itachi Uchiha, who was tasked with eliminating the entire Uchiha clan. This traumatic event deeply impacted Sasuke, fueling his desire for revenge and shaping his character throughout the Naruto series.
The tragic loss of his parents left Sasuke orphaned and instilled in him a profound sense of loneliness and anger. He dedicated his life to becoming stronger and eventually confronting Itachi to seek revenge.
