Itachi Uchiha did not have a girlfriend who died. The character of Itachi Uchiha, as portrayed in the Naruto anime and manga series, is primarily focused on his role as a shinobi and his complex relationship with his younger brother, Sasuke. He is not depicted as having a romantic relationship with anyone, let alone one that ended in death.
While there are many fictional characters in the Naruto universe who experience loss and tragedy, including Itachi himself, the character of Itachi does not have a girlfriend who dies.
